research
Using cutting-edge technology to uncover interactions of the two most complex systems - the immune system and the nervous system.
Elucidating the Pathophysiology of Antibody-mediated Diseases
Disease Risk Prediction and with Deep Phenotyping and AI
Developing Novel Areatments for Autoimmune Encephalitis
The central mission of our lab is to understand how neuronal autoantibodies disrupt the nervous system and to translate these insights into next-generation, precision interventions for antibody-mediated brain disease.
We investigate how disease-relevant antibodies emerge, engage neuronal targets, and disturb neural circuits across a spectrum of antibody-mediated neurological disorders. By integrating high-throughput antibody discovery, single-cell omics, and machine-learning strategies that connect molecular, cellular, imaging, and clinical data, we generate comprehensive maps of antibody action that guide targeted intervention strategies.
Our group bridges bench and bedside: many members are clinicians, so every experiment addresses the need to shorten diagnostic delays, improve prognostic accuracy, and offer effective therapies for our patients. Science advances fastest when shared openly and built by diverse minds. We therefore prioritize open data, inclusive team science, a collaborative environment, and an entrepreneurial spirit that turns discovery into impact.
Our lab lab is located at the Department of Neurology and Experimental Neurology at Charité – Universitätsmedizin Berlin. Our work is supported by generous funding by the Emmy Noether Programme of the Deutsche Forschungsgemeinschaft, as well as other government grants and private foundations.
